Grace McDaniels (March 14 1888 – March 17 1958) had an extremely severe deformity that gave her grotesque facial features. In 1935, she won “The Ugliest Woman” contest, which lead her to a lucrative career with the Harry Lewiston’s Traveling Circus. McDaniels was known as “The Ugliest Woman in the World,” and the “Mule-Faced Woman.”
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A Severe Facial Deformity
CT scan showing the brain of a 20 month old child with Sturge–Weber syndrome.
According to many sources on the Web, McDaniels likely suffered from a rare congenital neurocutaneous disorder called Sturge–Weber syndrome (or encephalotrigeminal angiomatosis).